By A. K. Szakal, Z. F. Kapasi, S. T. Haley (auth.), Marie H. Kosco-Vilbois (eds.)
Follicular dendritic cells (FOe) are specific between cells of the immune method. whereas their morphological features re sulted of their inclusion as a 'dendritic mobilephone type', tt1ey fluctuate relatively considerably from the opposite contributors of the dendritic cellphone kinfolk. unlike T-cell-associated dendritic cells or the Langerhans cells present in the outside, FOe live in hugely equipped B cellphone follicles inside of secondary lymphoid tissues. This website of resi dence supplied a nomenclature committee in 1982 with the second one descriptive issue for the derivation in their identify. The cardinal characteristic of FOe is to catch and maintain antigen at the floor in their dendritic methods for prolonged quantities of time and it's this selection that gives the conceptual compo nent for the identify of this ebook. according to an antigenic problem, basic B phone follicles suffer dynamic occasions, giving upward thrust to germinal facilities that are linked to activation, enlargement, and differentiation procedures of B cells. The interactions of B cells with Foe and T cells within the germinal facilities are crucial for producing the whole repertoire of antibody isotypes received in the course of an antibody reaction. moreover, stimuli both initiated or major tained throughout the germinal middle reponse results in creation of excessive affinity antibodies in the course of the procedures of somatic muta tion and clonal choice. during this context, FOe act as a pivotal resource of antigen. They gather international proteins (e. g.
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Additional resources for An Antigen Depository of the Immune System: Follicular Dendritic Cells
We must thus decipher these restraining and tolerizing systems in order to comprehend the physiology of the germinal centers. Follicular Dendritic Cells: Origin and Function 27 After primary antigen injection, B cells go through a tolerization-sensitive window shortly after being stimulated by antigen, if they encounter that antigen is soluble form in the absence of concomitant T cell help (LINTON et al. 1991). Newly emerging memory B cells are highly susceptible to inactivation. For example, hapten-specific B cells can be blocked by recognition of a hapten on a carrier in the absence of T cells specific for oligopeptides of that carrier; the B cells consequently pass through a second tolerization-sensitive window (LINTON et al.
1991 b) Are germinal centers insulating microenvironments? In: Imhof BA, Berrih-Aknin S, Ezine S (eds) Lymphatic tissues and in vivo immune responses. Dekker, New York, pp 365-368 Heinen E, Tsunoda T, Marcoty C et al. (1991 c) The germinal centre-a monastery or a bar. Res Immunol 142:242-244 Heinen E, Tsunoda R, Marcoty C et al. (1993) Follicular dendritic cells: isolation procedures, short and long term cultures. Adv Exp Med Bioi 329: 333-338 42 E. Heinen et al. Heusermann UH, Zurborn UH, Schroeder l, Stutte HJ (1980) The origin of the follicular dendritic cell: an experimental enzyme-histochemical and electron rnicroscopical study of the rabbit spleen.
1985). B cells fractionated into IgD+ and IgD- populations gave rise, in each case, to germinal center precursors (SEIJEN et al. 1988; VON DER HEIDE and HUNT 1990). LINTON et al. (1991) suggest that these precursors may reside in the J 11 Dpoor population. J11 D (CD24) appears as a cell adhesion molecule expressed on immature Band T cells (KADMON et al. 1992). According to TSIAGBE et al. 1992), the J11 D-rich cells may terminally differentiate into antibody-forming cells and thus never reach the centers.
An Antigen Depository of the Immune System: Follicular Dendritic Cells by A. K. Szakal, Z. F. Kapasi, S. T. Haley (auth.), Marie H. Kosco-Vilbois (eds.)