Get Airway Mucus: Basic Mechanisms and Clinical Perspectives PDF

By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)

ISBN-10: 3034888740

ISBN-13: 9783034888745

ISBN-10: 3034898096

ISBN-13: 9783034898096

Conceptually unsavoury, airway mucus is key to homeostasis within the respiration tract. against this, whilst irregular, mucus contributes considerably to the pathophysiology of a few critical bronchial ailments, together with bronchial asthma, power bronchitis and cystic fibrosis. This quantity presents vast ranging and in-depth assurance of the medical and scientific elements of airway mucus. It commences with introductory chapters which handle the biochemical and molecular organic foundation of airway mucus and maintains with complete insurance of a few of the physiological and rheological elements of breathing secretions. The medical facets of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory illnesses of the airway. the quantity concludes with a dialogue of the healing points of the subject, either when it comes to the prospective techniques to the remedy of mucus hypersecretion and the interplay of those medicinal drugs with airway mucus. Written via best specialists within the box, each one contribution presents a entire assessment of its specific topic. Reflecting the most recent advances during this very important sector of breathing study, this quantity may be of significant curiosity to scientists and clinicians operating within the box of airway secretions and comparable areas.

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Extra resources for Airway Mucus: Basic Mechanisms and Clinical Perspectives

Example text

In cystic fibrosis, a more sulphated mucin population was predicted [69], and indeed a sulphated species, not observed to any great extent in secretions from apparently normal airways, has been isolated from CF sputum [60]. A sulphated population ofmucins was also produced from cultured nasal epithelial cells from a person with cystic fibrosis [70]. In contrast, the expected increase in acidity of chronic bronchitic mucins [68] was not evident in the gel-forming species purified from the sputum of a number of individuals [7].

Glycosylation ofAirway Mucins MUC proteins provide the scaffolding for the extensive post-translation 0glycosylation that results in mature mucins (Figure I). Little is yet known about the specificity of O-glycosylation in airway epithelial cells, although numerous O-glycosidic oligo saccharides (O-glycans) have been isolated from airway mucins [9]. O-glycans are structurally heterogeneous [10] and are categorized by four major core type structures [11] to which galactose and/or N-acetylglucosamine are sequentially attached to produce elongated or branched oligosaccharides.

In our most recent investigations, we have analysed respiratory secretions in order to assign a genetic identity to each of the gel-forming, oligomeric mucin species present and determine whether they are present as different glycoforms. To this end, we have employed density-gradient centrifugation, ionexchange chromatography and agarose gel electrophoresis to identify three mucin populations which together comprise the bulk of the gel-forming species [46, 47, 62], and an example is shown in Figure 3.

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Airway Mucus: Basic Mechanisms and Clinical Perspectives by John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)


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