By John R. Baker, Ralph Muller, David Rollinson
Advances in Parasitology is a sequence of in-depth reports on present themes of curiosity in modern parasitology. It comprises clinical stories on parasites of significant impression, comparable to trypanosomiasis and scabies, and extra conventional components, reminiscent of zoology, taxonomy, and lifestyles heritage, which form present considering and purposes.
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Additional info for Advances in Parasitology, Vol. 48
It should perhaps be borne in mind, however, that the evolutionary significance of non-coding sequences is still poorly understood, since the constraints on mutation of these sequences are quite different from those governing the evolution of the organism as a whole. 6. Outlook There is now a substantial body of molecular evidence for a Neotropical origin of the modem genera Leishmania and Endotrypanum. DNA and RNA polymerase gene phylogenies have proved invaluable for the classification of the major Leishmania species complexes; however, some parts of even these phylogenies are still not strongly supported and it will be necessary to include additional taxa and possibly to employ additional genes before the true species phylogeny of Leishmania can be determined with confidence.
Schizotrypanum) species or subspecies. The tree is based on an alignment of 2194 nucleotide positions, using T. dionisii as an outgroup (see Figure 4). Full details of taxa are given by Stevens et al. (1999a). Analysis was perfomed using PAUP* 4 (Swofford, 1998). THE MOLECULAR EVOLUTION OF TRYPANOSOMATIDAE 21 within the southern supercontinent some 80-50 mybp as a parasite of marsupials, which subsequently diversified in the Neotropics when the advent of Triatominae provided vectors able to pass the original T.
Cruzi were substantially different in both size and sequence, and that the repeat unit could be used as a speciesspecific DNA probe for T. rangeli. Polymerase chain reaction (PCR) amplification, using both miniexon and kinetoplast DNA minicircle primers, has been used to distinguish sylvatic from domestic strains of T. , 1994, 1999). In Brazil, Steindel et aL (1998) examined T. rangeli, T. cruzi and a range of hat trypanosomes by isoenzyme and RAPD analysis and found they fell into three genetically distinct groups.
Advances in Parasitology, Vol. 48 by John R. Baker, Ralph Muller, David Rollinson