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By John D. Pickard, Nejat Akalan, Vladimir Benes, Concezio Di Rocco, Vinko V. Dolenc, J. Lobo Antunes, Johannes Schramm, Marc Sindou

ISBN-10: 3211994807

ISBN-13: 9783211994801

The ambition of all profitable editorial forums has been to supply a chance for mature scholarship and mirrored image, no longer limited through man made limits on area. The sequence presents a outstanding acocunt of growth over the last 35 years, either in regards to advances, exact descriptions of ordinary operative methods and in-depth studies of proven wisdom. the current quantity is a brand new enterprise and identity inquisitive about a unmarried subject specifically - low-grade gliomas. It features a multidisciplinary method that are meant to entice either skilled neurosurgeons and younger neurosurgeons in education alike.

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Extra info for Advances and Technical Standards in Neurosurgery, Vol. 35: Low-Grade Gliomas

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The former group may be suitable for more aggressive therapy at diagnosis. In addition, markers that provide warning of likely transformation may allow early intervention. Clinical trials are needed to determine the utility of these imaging biomarkers in a clinical setting. Acknowledgements I wish to thank Dr. Mary McLean from the CRUK Cambridge Research Institute for providing the MRS images. References 1. Al Okaili RN, Krejza J, Woo JH, Wolf RL, O’Rourke DM, Judy KD, et al. (2007) Intraaxial brain masses: MR imaging-based diagnostic strategy – initial experience.

1997) Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study. J Neurosurg 87(4): 516–24 139. Thiel A, Pietrzyk U, Sturm V, Herholz K, Hovels M, Schroder R (2000) Enhanced accuracy in differential diagnosis of radiation necrosis by positron emission tomography-magnetic resonance imaging coregistration: technical case report. Neurosurgery 46(1): 232–34 140. Tofts PS, Benton CE, Weil RS, Tozer DJ, Altmann DR, Jager HR, et al.

Another common alteration in diffuse astrocytomas is overexpression of the platelet-derived growth factor receptor alpha (PDGFRA) and its ligand PDGFalpha, thereby enabling an autocrine growth stimulation of the tumor cells [31]. PDGFRA amplification, however, is restricted to a small subset of high-grade gliomas, in particular glioblastomas [23]. Karyotyping and comparative genomic hybridization analyses revealed trisomy 7 or gains of chromosome 7q as a common genomic imbalance, which is detectable in up to 50% of diffuse astrocytomas.

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Advances and Technical Standards in Neurosurgery, Vol. 35: Low-Grade Gliomas by John D. Pickard, Nejat Akalan, Vladimir Benes, Concezio Di Rocco, Vinko V. Dolenc, J. Lobo Antunes, Johannes Schramm, Marc Sindou


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