Download PDF by Drew Provan: ABC of Clinical Haematology, 3rd Edition (ABC Series)

By Drew Provan

ISBN-10: 1405153539

ISBN-13: 9781405153539

ISBN-10: 1444312685

ISBN-13: 9781444312683

This ABC has demonstrated itself as a favored advent to medical Haematology, correct either for postgraduate scholars and first care practitioners. Now in its 3rd version, the ABC of medical Haematology has been completely revised, that includes the most recent remedies for leukemia, antithrombotics and medicine for lymphoma and protecting the most recent advances in hematology and bone marrow transplantation. With each one bankruptcy written by means of experts of their respective fields, this is often a fantastic simple textual content for common perform and health facility employees with sufferers who've blood comparable difficulties, particularly GPs, hematology nurses, junior medical professionals, hematologists, and trainees in hematology.

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Additional info for ABC of Clinical Haematology, 3rd Edition (ABC Series)

Example text

It has demonstrated considera- Chronic Myeloid Leukaemia ble efficacy in patients resistant to imatinib and patients who respond well should probably be continued on the drug indefinitely. The recommended dose is currently 100 mg daily. Nilotinib This agent, also a second generation tyrosine kinase inhibitor, is also active in patients whose leukemia appears resistant to imatinib. The currently recommended dose is 800 mg daily. At present there is no clear reason for preferring dasatinib to nilotinib or vice versa.

Full blood count The blood count is nearly always abnormal in acute leukaemia. Patients with acute leukaemia commonly present with circulating leukaemic blasts in the peripheral blood resulting in a raised white blood count. This will usually be accompanied by thrombocytopenia, neutropenia and anaemia. In a proportion of patients, the white blood count will be normal or reduced. Coagulation Thrombocytopenia is a common cause of petechial bleeding or bruising. Disseminated intravascular coagulation (DIC) is often present in newly diagnosed patients with acute leukaemia and may result in life-threatening bleeding complications.

Glycoprotein receptors react with aggregating agents, such as collagen on the damaged vascular endothelial surface and fibrinogen and von Willebrand factor (VWF), to facilitate platelet–platelet and platelet–endothelial cell adhesion. The major glycoproteins are the Ib/IX complex, the main binding protein of which is VWF, and IIb/ IIIa, which specifically binds fibrinogen. Storage organelles within the platelet include the ‘dense’ granules, which contain nucleotides, • A full bleeding history, drug history and review of the peripheral blood film are of primary importance in the differential diagnosis • Increasingly, molecular diagnosis is useful in congenital abnormalities • Available treatments depend on the diagnosis: • Platelet concentrates (contraindicated in TTP) Normal platelet function Fibrinogen von Willebrand factor Dense granules contain ADP,ATP,5HT ADP, ATP, 5HT,etc.

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ABC of Clinical Haematology, 3rd Edition (ABC Series) by Drew Provan


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